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Related studies mainly focus on in vivo intervention efficacy validation, exploration of combined intervention strategies, and optimization of pharmaceutical dosage forms, providing important experimental evidence for clinical intervention of obesity
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The first is extracellular matrix biology, where fibroblast culture and rat wound-chamber studies from the Maquart and Simeon groups (1988-2000) reported stimulation of collagen synthesis, sulfated glycosaminoglycan synthesis and small proteoglycan expression, alongside upregulation of matrix metalloproteinase-2 and its tissue inhibitors, a simultaneous increase in both matrix deposition and matrix turnover
Neither type of evidence should be treated as interchangeable with human clinical evidence
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