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All of them represent approaches that have emerged from clinical observation, practitioner experience, and the practical reality that many people cannot tolerate the standard 2.5 mg starting dose without significant gastrointestinal distress

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Graphical Abstract Access this article Similar content being viewed by others Data availability The datasets generated during and/or analyzed during the current study are available in the University of Arizona Data Repository ( or in the Virginia Tech Data Repository (VTechData

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The general consensus is that any increased risk of retinopathy with GLP-1 RA treatment is likely to be related to the abrupt improvement in glycemic control [108], a phenomenon similar to that reported for other neuropathological complications [109]

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The super long healing times with ablative lasers is another concern

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