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Furthermore, the residue could contribute to the stabilization of the thiolate of the catalytic cysteine as reported for human Grx1 (ref
While the animal model treated with PBS did not show any signs for ROS, high amounts of fluorescence signals in the tissue from the animal treated with NP4 were observed (Supplementary Fig
Because each session takes about 30 minutes and requires no recovery period, it fits easily alongside other treatments or a patients regular routine
This was based on our previous reports that incubating primary murine Ms with oxLDL or cholesterol is a reproducible method of lipid loading Ms, and this significantly upregulated NRF2-dependent transcriptional regulation after LPS stimulation [6,25,26]
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