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it acts largely as a messenger

TL;DR: In a large sample of US Veterans, GLP-1 drugs were associated with reduced risk of substance use and psychotic disorders, seizures, neurocognitive disorders (including Alzheimers disease and dementia), coagulation disorders, cardiometabolic disorders, infectious illnesses and several respiratory conditions, but increased risk of gastrointestinal issues, hypotension (low blood pressure), and some kidney-related conditions

The combination of all three pathways creates what researchers describe as a comprehensive metabolic reset simultaneously reducing caloric intake through appetite suppression, improving how the body processes nutrients, and increasing the rate at which the body burns stored fat

According to the warning, dulaglutide (the active ingredient in Trulicity) was found to cause an increased risk of thyroid C-cell tumors in male and female rates