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The cardiovascular safety of TRESIBA was evaluated in one double blinded, event driven trial of 2 year median duration in patients with type 2 diabetes at high risk of cardiovascular events [see Clinical Studies ]
* Correspondence: Jonghan Kim, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
A dominant-negative human G s (DNG s ) with 8 mutations (S54N, G226A, E268A, N271K, K274D, R280K, T284D, and I285T) was generated as previously described to limit G protein dissociation 51
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