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High levels of melanin result in darker skin, while reduced melanin leads to lighter skin

Yuan T, Yang T, Chen H, Danli Fu, Yangyang Hu, Wang J, Yuan Q, Hong Yu, Wenfeng Xu, Xie X (2019) New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis

Combined these results indicated that NP4 catalyzes the generation of H 2 O 2 in tumor cells, which diffuses outside the cells and activates macrophages, thereby triggering immune responses