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PMID: 27423583

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High-density SNP array and whole exome sequencing analyses showed no evidence of inactivating NF1 mutations in either 2XSB cells or their parent tumor and we demonstrated that 2XSB cells expressed functional full-length neurofibromin protein, indicating that 2XSB cells are derived from the subset of sporadic MPNSTs that have intact NF1

We recommend booking a skin check if you notice: A lesion or patch that wont heal after a few weeks A spot that bleeds spontaneously or forms a persistent scab A new bump or rough area that looks or feels different Its always better to be safe and have a professional assess your skin especially if you live in an area with higher sun exposure