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Elkomy A, Abdelhiee EY, Fadl SE, Emam MA, Gad FAM, Sallam A, Alarifi S, Abdel-Daim MM, Aboubakr M (2020) L-carnitine mitigates oxidative stress and disorganization of cytoskeleton intermediate filaments in cisplatin-induced hepato-renal toxicity in rats

As a consequence of iron overload, dysplastic changes and detrimental effects on erythroblast differentiation and maturation resulting in a reduction of the proliferative capacity of erythropoiesis and of erythroblast apoptosis in vitro have been described (23)

Unlike prior studies emphasizing single-organ effects, our analysis reveals that ferroptosis drives a self-reinforcing cycle: Hyperglycemia in DM triggers systemic iron overload, and the accumulation of iron in peripheral organs, combined with oxidative stress imbalance, causes organ damage (including pancreatic -cells), further exacerbating the progression of DM and forming a pathological feedback loop

This class of medications mimics GLP-1 (Glucagon Like Peptide) which promotes weight loss by reducing hunger, increasing feelings of satiety (feelings of fullness) and creating an overall reduction in food (calorie) intake