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Vitamin B6 (Pyridoxine) acts as a necessary cofactor in the folate cycle and combines with serine hydroxymethyl transferase to effect the conversion of tetrahydrofolate(THF) to 5,10 methylene THF (14)

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While knockdown of SNX1 or SNX2 resulted in vacuolar mislocalization and enhanced degradation of GFPVSR2, it remains unclear whether VSRs constitute direct cargo of SNX proteins

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