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Finally, to ensure that the depletion of serum B 12 levels and its associated low levels of Met were not simply caused by defective oral uptake due to the reprogramming of several digestive organs, we administered a large bolus of vitamin B 12 (5 g per mouse, 100 times the recommended dietary allowance 41 ) on day 6 of doxycycline treatment, 1 day before euthanasia (Fig
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These restrictions protect public health while allowing scientific investigation
Glutathione transporter as a target for brain-targeting drug delivery The first report using GSH as a brain targeting agent was from Wang et al
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