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GLP-1 then passes the baton to the next team member, the pancreas, to secrete insulin

Meta-analyses of hypertension treatment show that every 10 mmHg reduction in systolic BP: Reduces risk of major cardiovascular events by 20% Lowers risk of heart attack by 17% Decreases risk of stroke by 27% Reduces risk of heart failure by 28% Retatrutide's 14 mmHg reduction translates to roughly a 25-30% decrease in cardiovascular event risk based on epidemiological models

doi: 10.1523/JNEUROSCI.3008-05.2006 104 MajeskiJAUpshurJK

Beyond its pancreatic effects, GIP receptors are found in adipose tissue and the brain, where they are believed to play a role in regulating fat metabolism, energy storage, and energy expenditure