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This results in a leaner, more toned physique
, - ALEKSANDAR APOSTOLOV | 2025-01-19 10:07:25 , 6 1 ? , 6
After stimulation with phototherapy, these melanoblasts migrate, differentiate into melanocytes, and proliferate into the epidermis, probably through the upregulation of the stem cell-associated gene, GLI1.40 The stratum corneum and viable epidermis of vitiligo lesions are increased in thickness compared to non-lesional skin.41 The lesional epithelium also has larger corneocytes, likely to compensate for the decreased expression of cornification components and, therefore, they result in a thicker stratum corneum in vitiligo lesions
In the nucleus, following heterodimer complex formation with transcription factors, like small Maf proteins (G/F/K) and c-Jun, Nrf2 complexes bind to the antioxidant response element (ARE), a regulatory enhancer region within gene promoters that upregulate antioxidant and anti-inflammatory defense processes (Cuadrado et al., 2019
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