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The KDs ability to alter the metabolic environment of HCC cells, enhance oxidative stress, and potentially sensitize tumors to chemotherapy or radiotherapy makes it a promising adjunct treatment (69)

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These people would otherwise rely on the availability of daily B12 shots to counter their inability to absorb B12 through the gut

Presumably, CDK5RAP2 transits together with the TuRC from the cytoplasm to the centrosome where CDK5RAP2 is incorporated into the PCM along with the bound TuRC