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Alignment between biological mechanism, clinical endpoints, and payer expectations is therefore a critical component of translational success

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Disease-Induced Weight Loss and Its Impact on Skeletal Health Anorexia Nervosa (AN) is a critical disorder of eating behavior, defined by extreme calorie limitation, a persistent dread of gaining weight, and a misperception of body shape, ultimately causing markedly reduced body mass

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high pharmacologic doses (1-3 g/day) can cause hypotension, insulin resistance, and hepatotoxicity

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