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The most common causes include B12 supplementation (particularly injections), liver disease releasing stored B12, haematological disorders increasing B12-binding proteins, and chronic kidney disease reducing B12 excretion
For example, individuals with NAFLD exhibit increased intestinal permeability and prevalence of small intestine bacterial overgrowth, and these factors are associated with the severity of hepatic steatosis 19
A double-blind, placebo-controlled trial on CB4211, which is an analog (synthetic version) of MOTS-c, found the compound to be "safe and well tolerated" under a single and multiple ascending dose protocol in adult humans
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