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Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases

In a concanavalin A (ConA)-induced immune hepatitis model, iNOS-related signaling pathways can regulate macrophage polarization through mechanisms involving mitogen-activated protein kinase (MAPK) pathways and thereby influence the intensity of inflammatory responses, indicating that a shift of arginine metabolism toward the NO-generating pathway may promote pro-inflammatory macrophage responses and aggravate hepatic immune injury (101)

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