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[3] Aroda VR, Bain SC, Cariou B, et al
You should consult a doctor if your dark black spot on lip: Changes in size Changes color Bleeds Becomes painful Grows rapidly Has irregular borders Any evolving dark black spot on lip should be evaluated professionally
A potential limitation of these trials is that they had a one-sequence crossover design and differences in observation/exposure periods could make it difficult to compare safety and tolerability profiles between treatment periods
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