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The C-terminal residues form a set of inter- and intra-molecular, antiparallel -bridges between hTrxR1 residues 495 hTrxR1 to 499 hTrxR1 and hTrx1 residues 72 hTrx1 to 75 hTrx1 as well as a mixed disulphide between U498C hTrxR1 and Cys32 hTrx1 (Fig

Arrow legend: Solid arrows denote positive signal flow/translocation

Rather than serving primarily as a signaling scaffolds, mitochondria-lysosome interfaces act as adaptive buffering modules that calibrate organelle turnover, degradative capacity and inflammatory stress in response to immune challenge (54) (Fig