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Future research employing larger samples and whole-brain analytic approaches will be essential to establish a more definitive map of brain regions modulated by GLP-1 RA administration during food cue processing
Several animal studies investigated the effects of liraglutide 122,123,124,125,126,127 and exendin-4 (refs
Two of them (GLP-1 and GIP) are already targets for approved drugs: GLP-1 alone for semaglutide (Ozempic, Wegovy), GLP-1 and GIP together for tirzepatide (Mounjaro, Zepbound)
Following this 12-hour treatment, islets used for DART-Seq were washed with PBS and dissociated into single-cell suspension using trypsin
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