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The global prevalence of type 2 diabetes has risen sharply in recent decades due to lifestyle changes, poor dietary habits, obesity, and aging populations [1]
In patients with type 2 diabetes, the medication also improved glycemic management
The larger pocket size of AtHTL might be the reason why AtHTL exhibited a slightly weaker affinity to KAR 1 than ShHTL1 and was able to hydrolyze rac -GR24 to some extent 26,34 and hydrolyze the synthesized desmethyl-YLG (dYLG), which is a smaller version of YLG 27
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