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The published TRIUMPH-1 and TRIUMPH-4 data suggest discontinuation rates due to adverse events climb with dose, and that the 12 mg arm of retatrutide has shown the highest discontinuation figures of the three compounds at their respective top doses in published Phase 3 trials [2][10]
Nausea: This is the most common complaint, especially when starting the medication or increasing the dose
Even mild dehydration reduces metabolic efficiency
That intake level often doesn't supply daily B12 requirements (2.4 mcg per day, per the National Institutes of Health)
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