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Indeed, L2HGDH silencing or addition of cell permeable L2HG reduced global DNA 5hmC modifications (Fig

K., Schulze, U

Lyzenga-Dean, "One study reported that 50% of patients taking GLP-1 agonists experienced nausea while taking them." The Rebound Effect Discontinuing GLP-1 medications often leads to weight regain

It remains unapproved as of mid-2025, with long-term safety and efficacy still under investigation in Phase 3 trials

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