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For RPE cells, iron overload-induced LPO and dysfunction of the system Xc-/GSH/GPX4 axis are confirmed as core pathogenic events in AMD (151)

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No significant differences were observed across metabotypes in TMAO AUC change between placebo and pomegranate interventions (Supplementary Figure 3), but mean TMAO AUC values differed between metabotypes following pomegranate intervention (Supplementary Figure 4)

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