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The International Association for the Study of Pain defines it as pain resulting from a stimulus that does not normally provoke pain, and that definition matters because it distinguishes allodynia from hyperalgesia, where painful stimuli simply hurt more than expected
Therefore, the upcoming phase III and post-marketing studies should stratify efficacy and safety endpoints by sex and menopausal status
Common adverse effects include gastrointestinal symptoms such as nausea, vomiting, diarrhoea, and constipation, which are typically mild to moderate and often diminish over time
Hellstrm, Uppsala University, Sweden I
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