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In mice, GDF-15 increases satiety and reduces food intake through actions in the central nervous system [99]

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, L- ,

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J-difference-edited MRS(Harris et al., 2017

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Collectively, the results discussed above could be interpreted to suggest that conditions likely to result in -cell stress, such as obesity, hyperglycaemia, and inflammation, activate compensatory responses in an attempt to improve -cell function and survival

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