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The nucleophile provides the electrons to form the new bond and the pi bond of the carbonyl group is broken as it "gets out of the way." The electrons move from this pi bond onto what was the carbonyl oxygen

Chronic misuse of alcohol that leads to repeated overdoses significantly increases the risk of developing lasting conditions such as alcoholic hepatitis, fibrosis, or cirrhosis of the liver, which are life-threatening

These metabolic axes take part in shaping the ferroptosis-susceptible cell-state collectively, and the relative contribution of each axis is likely dictated by the cellular contexts and by the specific ferroptosis-inducing approaches (Fig