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Thus, although GIPR in the AP is required for the weight loss effects of GIPR agonists, it is not the target of therapeutic GIPR antagonists, supporting recent findings that Gipr KO in GABAergic neurons also abolished responses to GIPR agonism but not antagonism 6
Interestingly, observational data from 200 WeightWatchers members showed that those who stopped GLP-1 medications while following a structured healthy habits program not only maintained their weight loss but even lost an additional 1.8% of their body weight over 13 weeks
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This could have been due to a number of factors, such as the role of gut bacteria preventing the return to the steady state
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