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The protective effects of metformin are attributed to multiple mechanisms, including the activation of the AMPK pathway, normalization of autophagy, reduction of oxidative stress, and inhibition of cardiomyocyte apoptosis [135]

Coenzyme-Q10 is a vital nutrient that acts as an antioxidant, supporting cellular energy production and improving sperm function

Paulus WJ, Tschpe C (2013) A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation

In Arabidopsis, arGST loss-of-function mutations were additionally linked with an increased content of flavonols 19,45 , most probably due to a second oxidation of accumulating flavan-3,3,4-triol ( 4 ), which is catalysed by At LDOX in vitro 11,12,13