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In type 2 diabetes studies, digestive side effects were reported by 37% to 44% of people on tirzepatide, compared with 20% on placebo
Despite an emerging consensus that these peripherally administered GLP1RAs exert their effects on appetite suppression through the central nervous system, knowledge of the neural pathways and intracellular signaling mechanisms by which they act in the brain remains limited
The most common side effects, such as nausea, tend to diminish over time as your body adjusts to the medication
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