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Subsequent trials, including SUSTAIN-6, Harmony Outcomes, and AMPLITUDE-O, reported similar MACE reductions but without a mortality benefit [15,16,17]
The weight that's coming off is more fat and less muscle loss, plus the patients will feel better and stronger (not just lighter)
Therefore, the acidic residues of p53 TAD appear to have no significant impact on its interaction with the FOXO4 FHD, as these residues primarily contribute to DNA selectivity rather than binding to the FOXO4 FHD
Source: Lang, C
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