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People with angina pectoris often experience symptoms when the demand for oxygen exceeds the capacity of the coronary circulation to deliver it to the heart muscle, e.g., during exercise

Additional mechanisms attributed to berberine in laboratory and animal studies include modulation of gut microbiota composition, inhibition of mitochondrial complex I, and effects on various signaling pathways including those involving insulin receptor substrate proteins

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By focusing on protein, fiber, exercise, gut health, and blood sugar stability, you can support the systems your body already uses to regulate appetite, energy, and metabolism