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Methylation is a fundamental biochemical process involved in detoxification, hormone metabolism, neurotransmitter production, DNA repair, and gene expression
In the setting of SARS-CoV-2, COVID-19 and oxidative stress, patients with comorbidities may have altered levels of glutamate-cysteine ligase and GSH synthetase, the enzymes participating in GSH synthesis
Future studies evaluating glutathione with a larger sample size with statistical power to differentiate the association proposal by manic or depressive episodes, as well as the use of NAC as a suicide risk reducer, seem justified
If dehydration is severe, it cant be resolved by simply drinking water
