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While the effects of structural diversity of CYP family proteins and interactions with different xenobiotic substrates should further be examined, the current results suggest that the interaction of drug-metabolizing CYPs with the haem-mediated dimer of PGRMC1 plays a crucial role in regulating their activities

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The following gRNA target sequences were employed to generate ARL8 DKO cell line: sgRNA for ARL8A : CGCGATCACGTTGACGAAGG, and sgRNA for ARL8B : AGAGATGGAGCTGACGCTCG 20

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