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The authors demonstrate that GLP-1R agonist treatment induces expression of tyrosine kinase IGF1R/ErbB (EGFR) pathways, however, agonist treatment can still increase intestinal growth in the absence of intestinal epithelial IGF1 receptor as well as EGF receptor signaling (Koehler et al., 2015)

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The clinical trial is a double-blind, randomized, placebo-controlled study to assess the efficacy and safety of administering semaglutide 2.4 mg in 150 obese Asian patients weekly