Both CTGF and its upstream regulator, TGF-, are implicated in the pathogenesis of glaucomatous optic neuropathy due to their roles in ECM remodeling
Treatment of Psoriasis In the 1980s, psoriasis was viewed as a keratinocyte-driven disease and the treatment employed was to inhibit proliferation of epithelial tissue using methotrexate, phototherapy, and retinoids
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It lightens gradually, but maintenance is needed to sustain results