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Why menopause and perimenopause make weight loss more challenging Combining hormone replacement therapy (HRT) with glucagon-like peptide-1 (GLP-1) receptor agonists has become an increasingly common approach for treating menopausal weight gain, particularly stubborn visceral fat around the midsection

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"While we acknowledge your response that an abrupt shortening of the enrollment period led to challenges and mistakes, your response is inadequate because, regardless of the length of the enrollment period, you are still responsible for ensuring that subjects meet protocol-specified eligibility criteria before you enroll them into the study," said FDA