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Concurrently, GO analysis of biological processes showed significant enrichment of the canonical Wnt signaling pathway, non-canonical Wnt signaling pathway, BMP signaling pathway, hair follicle development, hair cycle, cell migration, and positive regulation of stem cell proliferation (Figure 4B)

Since the great majority of circulating IGF-I is normally sequestered in IGFBP complexes, an analogue that escapes that buffering behaves very differently in any system containing binding proteins, and that is the reason the IGF 1 LR3 variant exists as a reagent at all

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