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In vivo experiments further confirmed that Ex-4 indirectly inhibits the proliferation and invasion of pancreatic cancer cells by suppressing PSC activity and extracellular matrix (ECM) deposition [39]

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These developments are consistent with the evolving understanding of the gastrointestinal tract as a key endocrine organ that regulates appetite, glucose homeostasis, energy expenditure, and gastrointestinal motility through a complex network of hormonal signals [20]

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