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In rabbits, but not rats, there was a statistically insignificant higher number of post-implantation losses at the maximum dose tested (600 mg / kg per day) than in the control group

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Nayan Patel: Humans

Pharmacokinetic comparisons between diabetic individuals and healthy individuals have shown that tirzepatide delays gastric emptying, particularly after a single dose, and demonstrates a decrease in effectiveness or responsiveness with repeated once-weekly dosing, referred to as tachyphylaxis [44, 72]