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Gut-microbiota-derived phenylacetylglutamine induces oxidative stress in endothelial cells via a NOX2-dependent pathway

Another relevant limitation is that the severity of symptoms was not incorporated into the analysis, which may influence the observed efficacy of antioxidant therapies, particularly in cases with more severe clinical presentations

Damiani G, Bragazzi NL, Karimkhani Aksut C, Wu D, Alicandro G, McGonagle D, Guo C, Dellavalle R, Grada A, Wong P, La Vecchia C, Tam LS, Cooper KD, Naghavi M (2021) The global, regional, and national burden of psoriasis: results and insights from the global burden of disease 2019 study

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