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Liraglutide activates the PKA/CREB pathway in the cartilage tissues of the knee OA rat model Western blot analysis was also used to detect the expression of PKA/CREB pathway components in the cartilage tissues of OA knees after treatment with liraglutide or saline

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Global IGF-1R knockout embryos exhibit more severe skeletal defects than igf-1 null animals and die shortly after death, suggesting that both IGF-1 and IGF-2 acting via their shared receptor are involved in regulating skeletal development in the embryonic stage

Insulin helps neurons use glucose, modulates synapses (the wiring that underlies memory), and dampens inflammatory cascades