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Vitamin C is a well-known antioxidant, a co-factor for collagen synthesis, helpful in carnitine and catecholamine biosynthesis, and also it facilitates dietary iron absorption
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In a study of colon cancer cells, COX-2 expression and PGE2 synthesis were upregulated by the IGF-2/IGF-1R autocrine pathway and IGF-1R blockade decreased COX-2 activity and inhibited tumor cell proliferation and promoted apoptosis (103)
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