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In experiments using melatonin, either melatonin (10mg/kg, Sigma) or an equivalent volume of DMSO (Sigma) was intraperitoneally injected each day for three days at 17:00, immediately after intranasal challenges had been performed

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By comparison, those taking Wegovy the highest-dose semaglutide formulation approved for weight loss lost up to 17.4% in a similar time period (68 weeks)