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26,27 Suggestive evidence of hemoglobin A1c-lowering being the cause of the reported worsening with GLP-1/GIP agonists can be derived by comparing the results of two recent retrospective cohort studies assessing retinopathy outcomes between subjects treated with GLP-1/GIP agonists and sodium-glucose cotransporter-2 (SGLT2) inhibitors
This metabolite was discovered to mitigate ectopic lipid deposition in renal tubular cells, indicating the presence of a gut microbiota5-OPkidney axis (potentially mediated by Clostridium5-OPELD), which may serve as a novel intervention target (Steven et al., 2017
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