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The ,-unsaturated enone moiety of resorcylic acid lactones is susceptible to Michael addition reaction with a conserved cysteine residue (Cys166 in human ERK2) (95)
Dark spots from old acne
because yeah, to your point when you could measure and you can actually see that difference, instead of just theoretically or just because you want to look the way someone looks on social media and you think its because you need more and more and more
Similarly, 4-aminobiphenyl, metabolized by hepatic CYP1A2, produces reactive intermediates that form DNA adducts in hepatocytes, increasing the mutational burden [27]
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