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When administered through injections at the appropriate doses and intervals, hunger levels decrease which leads to lower food intake, promoting significant and sustained weight loss
N Engl J Med 2017;377:83948.ArticlePubMed 18
GLP-1 and glucagon promote weight loss through distinct mechanisms of action GLP-1 is believed to act predominantly in the hypothalamus to induce satiety, whereas the weight-lowering effects of glucagon are mostly driven by its lipolytic and thermogenic effects in liver and the adipose tissue [56]
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