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Each receptor contributes something unique to the overall metabolic effect, and their combined activation produces outcomes that no single-receptor agonist can match

The report highlighted the limitations of BMI, and instead the Commission recommends combining BMI with waist circumference, waist-to-height ratio, and clinical markers of organ dysfunction to diagnose obesity accurately

Conclusion It is entirely possible to lose weight effectively without GLP-1 agonists by relying on natural methods such as a healthy diet, regular physical activity, and thoughtful lifestyle changes