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This condition causes oxidation of low-density lipoprotein, diminishes nitric oxide synthesis and leads to arterial stiffness, endothelial inflammation and foaming

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Sodium-glucose co-transporter 2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists have been recommended for the treatment of type 2 diabetes for some time, but until now have not been funded in New Zealand

The apparent absence of the bone mineral density preservation effect seen with liraglutide in MC4R -deficient patients, unlike in common obesity, underscores the need for vigilant bone health assessment and potential adjunctive interventions in this group