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Weight loss is a primary driver of downstream hormonal benefits, with semaglutide producing up to 15% body weight reduction over 68 weeks and a 2025 trial reporting a mean loss of 5.6 kg, compared with 2.3 kg with other treatments

Men with low testosterone often gain fat and lose muscle testosterone replacement injections can stimulate fat loss and increased muscle mass

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While the medication may contribute to conditions causing minor bleeding, it does not explain significant or persistent hemorrhage