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The imbalance between the antioxidant defense system and the generation of oxidants creates oxidative stress which can further cellular damage and compound adverse issues from chronically impaired sleep such as obesity and even neurodegenerative disorders

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However, there are only a handful of clinical studies in healthy subjects (mostly females) that have evaluated the effects of BTR signaling on gut hormone secretion and associated metabolic effects, and no studies in patients with obesity and/or type 2 diabetes

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